Dermamelan® is the medical depigmenting method that efficiently and progressively eliminates spots by acting on the accumulation of pigment in the skin and on the root of the problem, providing a comprehensive and long-lasting outcome.

What Is Dermamelan?

Dermamelan has similar active ingredients to Cosmelan but at 20 % higher concentration and the mask treatment and follow up must be done under strict supervision of a cosmetic doctor. Dermamelan treatment guarantees the improvement of skin blemishes with a very high safety margin. Dermamelan Depigmentation treatment’s principal action is the elimination of melanin patches on the face – melasma, also called chloasma if the pigmentation occurs with pregnancy. Dermamelan Depigmentation treatment involves a very versatile, dynamic process which is easily adapted to the needs of each individual patient.

What does Dermamelan treat?

Skin ageing caused by systematic sun exposure, facial blemishes due to excessive pigmentation and, in general, imperfections caused by melanin, are more and more common problems today. “Dark blemishes”, especially on hands and face, are one of the greatest aesthetic concerns of modern men and women… It will only be possible to remove the anti-aesthetic skin blemishes and recover the smoothness of the skin, bringing back its luminosity, with a treatment that has a direct effect on the intimate formation process of the pigment (melanin).

How does Dermamelan work?

Dermamelan Depigmentation treatment action mechanism is based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Dermamelan formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain. Melanogenesis comprises the following stages:

  1. TYROSINE proceeds to DOPA by means of TYROSINASE.
  2. DOPA proceeds to DOPAQUINONE by means of TYROSINASE.
  3. DOPAQUINONE proceeds to PHAEOMELANINE and EUMELANIN by means of oxidation and cyclization.
What are the advantages of a Dermamelan?

The Dermamelan Depigmentation treatment offers a series of major advantages and benefits compared with other types of depigmentation products found in the market:

  • Very effective in all types of Melasma especially deep-seated severe Melasma or post-inflammatory hyperpigmentation PIH
  • Effective for pigmentation that has failed to resolve after traditional skin lightening products
  • Effective for pigmentation that has failed to resolve after traditional treatments such as superficial peels
  • Rapid and easy depigmenting action
  • Compatible with ALL skin types (Fitzpatrick I – VI)
  • Light peeling effect
  • Rejuvenates the skin
  • Treatment can be used all year round
  • Beneficial for acne patients
  • Does not contain Hydroquinone or TCA
  • High safety margin
What results can be expected from a Dermamelan?

In 99% of the cases, the disappearance of the blemishes improves by 95%…

ONE WEEK after starting the Dermamelan Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present. At the end of the Dermamelan Depigmentation treatment, the blemishes start to disappear altogether, so that, although the patient may be able to “locate” the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it.

What conditions can be treated with Dermamelan?

Dermamelan works by blocking the process that causes hyperpigmentation. It works for:

  • Melasma
  • Brown Spots
  • Blotchy Skin
  • Hyperpigmentation post acne spots
  • Post-inflammatory hyperpigmentation
  • Prevention of hyperpigmentation post-laser and post-peel
What can be expected after a Dermamelan treatment mask?

First and second day

During the first two days of the treatment, the skin may turn red. If the skin is very sensitive, the patient may experience an itching feeling. Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment. To relieve these problems, it is advisable to apply the Mesoestetic® Hydra-vital factor K whenever necessary.

Reddening of the Skin that occurs on the face after applying the Mesoestetic® Dermamelan mask treatment; is similar to the effects of day-long exposure to the sun or the snow without sun protection (Intense reddening in skin type I and II and practically non existent in skin type IV and V).

Flaking may occur on all skin types (and more intensely in skin type I and II) between the second and third day. In this case it is advisable to apply the Mesoestetic® Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense repeating this every 2 hours until it improves. Do not pull on the flakes. Do not rub or scratch the skin. If necessary flakes can be cut off. Do not use exfoliants, scrubs or peels. Avoid steam baths, saunas and swimming in a hot spring for 2 weeks following treatment. It is advisable to wait until the initial flaking period is over before starting to apply make-up again.


If a severe skin reaction results from treatment do not proceed with maintenance treatment. Similarly, if scab formation is seen or if the skin is accidentally injured during the treatment period it is advisable to interrupt application of maintenance treatment. Use only Hydra-vital factor K and Sunscreen until the skin has settled and then again proceed with the maintenance treatment schedule. If in doubt, please contact your doctor at Skin Renewal immediately.

Third and fourth day

After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

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